Characterizing the factors contributing to the differential immune responses to vaccinations
​Using transcriptomics to explore the genomic/gene module-based changes associated with vaccine response in a heterogenous population through a comparative framework.
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This manuscript is currently under preparation, and the project is embedded within the VITAL consortium
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Stay tuned for the manuscript!
Using umbrella sampling and metadynamics to study molecule permeation
Antibiotic molecules aimed at specific bacterial targets often permeate into the bacterial cell through surface protein channels. How do the energy profiles of this permeation process look like? ​
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This study was published in the JCTC (Journal of Chemical Theory and Computation) journal and is available at this link​
Regulatory evolution through population and comparative genomics
Understanding the impact of natural selection acting on the regulatory motifs participating in the TF-DNA interactions across multiple species and populations.
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This manuscript is currently live on GBE and can be accessed here​
CMV infection influences long-term T-cell immunity and vaccine responses in cancer patients, with stronger CMV reactivity linked to better SARS-CoV-2 responses. CMVision is an open-source ELISpot tool for precise analysis of complex T-cell activity
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The manuscript is live on biorxiv
ELISpot scoring pipeline for accurate analysis of T cell responses - CMVision
Impact of selection on the regulatory non-coding elements
Gene regulatory elements (GREs) directly influence the genotype-to-phenotype transitions. Given their functional importance, what role does natural selection play in their evolution? ​
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Click here to view our review summarising what we know so far ​
Bridging bioinformatics and chemoinformatics
In this book chapter, we highlighted how high-throughput technologies and AI have advanced bioinformatics and chemoinformatics, and how integrated interdisciplinary datasets are bridging these fields to drive progress in areas like structural biology and pharmacology.
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Click here to read ​
